tert-Butyl 4-iodo-3-methylphenylcarbamate
tert-Butyl (4-iodo-3-methylphenyl)carbamate
CAS: 1221793-58-3
Molecular Formula: C12H16INO2
tert-Butyl 4-iodo-3-methylphenylcarbamate - Names and Identifiers
| Name | tert-Butyl (4-iodo-3-methylphenyl)carbamate |
| Synonyms | N-BOC 4-iodo-3-methylaniline tert-Butyl 4-iodo-3-methylphenylcarbamate tert-Butyl (4-iodo-3-methylphenyl)carbamate |
| CAS | 1221793-58-3 |
tert-Butyl 4-iodo-3-methylphenylcarbamate - Physico-chemical Properties
| Molecular Formula | C12H16INO2 |
| Molar Mass | 333.17 |
| Storage Condition | Room temperature. |
| Sensitive | IRRITANT |
| MDL | MFCD16036101 |
tert-Butyl 4-iodo-3-methylphenylcarbamate - Introduction
tert-Butyl (4-iodo-3-methylphenyl) is carbamate an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: tert-Butyl (4-iodo-3-methylphenyl)carbamate as white or slightly yellow crystals.
-Molecular formula: C13H18INO2
-Molecular weight: 349.19g/mol
-Melting point: about 60-65 ℃
-Boiling point: about 242-244 ℃
Use:
- tert-Butyl (4-iodo-3-methylphenyl)carbamate is a commonly used organic synthesis reagent.
-It plays an important role in the synthesis of organic compounds and can be used to construct the skeleton of a variety of compounds.
-In addition, tert-Butyl (4-iodo-3-methylphenyl)carbamate is also widely used in drug synthesis.
Preparation Method:
The preparation of tert-Butyl (4-iodo-3-methylphenyl)carbamate can be carried out by the following steps:
1. First, 4-methyl aniline is reacted with iodinated alkyl (such as methyl iodide) under alkaline conditions to generate 4-iodine -3-methyl aniline.
2. Then, the generated 4-iodo-3-methylaniline is reacted with tert-butyl chloroformate (Boc-Cl) under basic conditions to form tert-Butyl (4-iodo-3-methylphenyl)carbamate.
Safety Information:
- tert-Butyl (4-iodo-3-methylphenyl)carbamate should be handled in accordance with the general safe practice of chemicals.
-Wear appropriate personal protective equipment, such as lab gloves and goggles, when in use.
-Avoid inhaling its powder or gas.
-When in contact with skin or eyes, rinse immediately with plenty of water and seek medical advice.
Nature:
-Appearance: tert-Butyl (4-iodo-3-methylphenyl)carbamate as white or slightly yellow crystals.
-Molecular formula: C13H18INO2
-Molecular weight: 349.19g/mol
-Melting point: about 60-65 ℃
-Boiling point: about 242-244 ℃
Use:
- tert-Butyl (4-iodo-3-methylphenyl)carbamate is a commonly used organic synthesis reagent.
-It plays an important role in the synthesis of organic compounds and can be used to construct the skeleton of a variety of compounds.
-In addition, tert-Butyl (4-iodo-3-methylphenyl)carbamate is also widely used in drug synthesis.
Preparation Method:
The preparation of tert-Butyl (4-iodo-3-methylphenyl)carbamate can be carried out by the following steps:
1. First, 4-methyl aniline is reacted with iodinated alkyl (such as methyl iodide) under alkaline conditions to generate 4-iodine -3-methyl aniline.
2. Then, the generated 4-iodo-3-methylaniline is reacted with tert-butyl chloroformate (Boc-Cl) under basic conditions to form tert-Butyl (4-iodo-3-methylphenyl)carbamate.
Safety Information:
- tert-Butyl (4-iodo-3-methylphenyl)carbamate should be handled in accordance with the general safe practice of chemicals.
-Wear appropriate personal protective equipment, such as lab gloves and goggles, when in use.
-Avoid inhaling its powder or gas.
-When in contact with skin or eyes, rinse immediately with plenty of water and seek medical advice.
Last Update：2024-04-09 21:01:54
